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. 2021 Feb 3;22(4):1536. doi: 10.3390/ijms22041536

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Desensitized/Open ratio expressed as a function of stimulation frequency. Simulations were performed using single pre-synaptic glutamate pulses of 1 mM amplitude and 1, 5, and 10 ms width. For each simulation, the ratio between the desensitized and the open fraction has been calculated for (A) AMPA (triangles, circles and diamonds symbols refer, respectively, to 1, 5 and 10 ms pulse width) and (B) NMDA receptors (crosses, circles and stars symbols refer, respectively, to 1, 5 and 10 ms pulse width).