Table 4.
Particle size of the initial active pharmaceutical ingredient (API), the nanosuspension, the physical mixtures, and the final samples. SSA, specific surface area.
| Samples | D[0.1] * (µm) | D[0.5] * (µm) | D[0.9] * (µm) | Span * | SSA * (m2/g) |
|---|---|---|---|---|---|
| raw MX | 2.719 ± 0.057 | 9.913 ± 0.371 | 29.49 ± 0.630 | 2.70 ± 0.043 | 1.09 ± 0.028 |
| MX suspension | 0.067 ± 0.001 | 0.138 ± 0.005 | 0.555 ± 0.310 | 3.584 ± 2.056 | 43.65 ± 5.318 |
| pmMX1_LEU0 | 3.073 ± 0.030 | 13.10 ± 0.500 | 349.92 ± 34.86 | 26.47 ± 1.649 | 0.88 ± 0.025 |
| pmMX1_LEU0.5 | 5.426 ± 0.631 | 91.22 ± 17.90 | 357.57 ± 168.2 | 3.86 ± 1.101 | 0.40 ± 0.066 |
| pmMX1_LEU1 | 7.983 ± 0.092 | 110.67 ± 0.261 | 353.25 ± 47.24 | 3.12 ± 0.433 | 0.27 ± 0.002 |
| nanoMX1_LEU0 | 1.497 ± 0.046 | 3.186 ± 0.019 | 6.481 ± 0.193 | 1.56 ± 0.068 | 2.22 ± 0.031 |
| nanoMX1_LEU0.5 | 1.834 ± 0.007 | 3.800 ± 0.014 | 7.389 ± 0.030 | 1.46 ± 0.004 | 1.88 ± 0.024 |
| nanoMX1_LEU1 | 1.977 ± 0.093 | 4.396 ± 0.032 | 8.903 ± 0.186 | 1.58 ± 0.075 | 1.71 ± 0.051 |
* Data are means ± SD (n = 3 independent measurements).