Table 9.
In vitro aerodynamic properties of the “nano-in-micro” systems. FPD, fine particle dose; FPF, fine particle fraction; ED, emitted dose; EF, emitted fraction.
| Samples | MMAD * (µm) | FPD * (mg) | FPF * (%) | ED * (mg) | EF * (%) | Loaded API * (mg) | API content * (%) |
|---|---|---|---|---|---|---|---|
| nanoMX1_LEU0 | 2.33 ± 0.08 | 4.52 ± 0.33 | 75.67 ± 3.46 | 5.98 ± 0.22 | 72.42 ± 3.05 | 8.26 ± 0.14 | 93.81 ± 2.99 |
| nanoMX1_LEU0.5 | 1.74 ± 0.35 | 3.09 ± 0.31 | 72.81 ± 1.46 | 4.24 ± 0.34 | 83.47 ± 1.33 | 5.07 ± 0.33 | 55.48 ± 0.78 |
| nanoMX1_LEU1 | 1.55 ± 0.06 | 2.51 ± 0.04 | 73.63 ± 0.96 | 3.40 ± 0.10 | 75.22 ± 1.75 | 4.53 ± 0.23 | 51.46 ± 0.66 |
* Data are means ± SD (n = 3 independent measurements).