Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 15;49(4):1987–2004. doi: 10.1093/nar/gkaa1291

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 8. — A proposed mechanism for RecOR loading of RecA protein onto ssDNA. Our results suggest a proposed mechanism for RecOR loading of RecA onto ssDNA (solid orange line) that is coated with SSB. (A) In this model, the SSB, while bound to ssDNA, recruits RecO via the C-terminal tip (SSB-Ct). (B) RecR, in a dimer-tetramer equilibrium, binds to RecO, which promotes tetramerization of RecR. (C) SSB-Ct bound RecO forms a complex with RecR, favoring the formation of a RecR₄O complex over a RecR₄O₂. The absence of the second RecO may facilitate the RecR₄ tetramer to recruit RecA to be loaded onto the ssDNA gap for repair. (D) SSB-Ct dissociates from RecR₄O complex, and SSB is displaced as RecA is loaded onto ssDNA.