Table 2.
Summary of included studies regarding FMT as a preventive strategy in allo-HSCT patients.
| First Author | Year | Indication | Number of Patients | Route of Administration | Donor | Main Results |
|---|---|---|---|---|---|---|
| Bilinski | 2017 | ARB decolonization | 20 with blood disorders (10 neutropenic, 4 aGvHD, 2 chronic GvHD) |
Nasoduodenal tube | Unrelated | 60% of patients achieved complete ARB decolonization at one month after FMT. |
| Innes | 2017 | ARB decolonization | 1 before allo-HSCT | Nasogastric tube | Unrelated | By day +16 after FMT, no ARB was detected on rectal screening swabs. |
| Taur | 2018 | Dysbiosis reduction | 25 (14 received FMT; 11 control group with no intervention) | Enema | Autologous | FMT patients had boosted microbial diversity and reestablishment of the intestinal microbiota composition they had before antibiotic treatment and allo-HSCT. |
| DeFililpp | 2018 | Dysbiosis reduction | 13 | Oral capsules | Unrelated | Improved intestinal microbiome diversity associated with expansion of stool-donor taxa. |
| Battipaglia | 2019 | ARB decolonization | 10 (6 before and 4 after allo-HSCT) | Enema or nasogastric tube | Unrelated or Relative | Decolonization was achieved in 7 out of 10 patients. |
| Merli | 2020 | ARB decolonization | 5 children before allo-HSCT | Esophagogastroduodenoscopy | Unrelated | Long-term decolonization was not achieved in four out of five patients. |
| Ghani | 2020 | ARB decolonization | 11 with blood disorders (8 before allo-HSCT) | Nasogastric tube | Unrelated | Decolonization in 41% of patients. Reduction in bloodstream infections. |
ARB: antibiotic-resistant bacteria; allo-HSCT: allogeneic hematopoietic stem cells transplantation; FMT: Fecal Microbiota Transplantation.