Figure 3.

Protein–protein interaction network between gene products with high-impact variants contained in the top enriched pathways and those presenting differentially methylated sites in CLZ-treated patients. Proteins are grouped by colors according to the pathway they are involved in (e.g., proteins in red: circadian entrainment; blue: insulin secretion; yellow: thyroid hormone signaling pathway; green: GABAergic synapse). Clusters are based on STRING analysis. The center of the figure highlights the close interactions between nodes.