Figure 4.

Synergistic effect of H₂O₂ and NO₂⁻ in inducing cancer cell death. CAL27 (a) and FaDu (b) were incubated in PBS containing H₂O₂ at 0.8 or 1.6 mM and increasing concentrations of NO₂⁻ from 0 to 3.2 mM. The red and blue dashed arrows highlight the fact that the same % of cell viability can be reached using the appropriate combination of H₂O₂ + NO₂⁻. Insets: cell viability of CAL27 (a) and FaDu (b) in the presence of increasing concentrations of NO₂⁻, NO₃⁻ and NO₂⁻ + NO₃⁻. The data are the mean ± SD of 2 to 4 independent experiments.