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Therapies which down-regulate YAP/TAZ activity.
| Drug | Target | Mechanism |
|---|---|---|
| Verteporfin | YAP | Up-regulates 14-3-3 |
| Dasatinib | Tyr inhibitor | Promotes proteasomal degradation of YAP/TAZ |
| Pazpanib | Tyr inhibitor | Promotes proteasomal degradation of YAP/TAZ |
| Cerivastin | HMGCoA reductase | Cytoplasmic sequestration of YAP/TAZ |
| XAV939 | Tankynase | Decreased YAP/TAZ-mediated expression |
| Statins | HMGCoA reductase | Cytoplasmic sequestration of YAP/TAZ |
| C19 | Activates MST1 and LATS1 | |
| MF-438 | SCD1 |
