Figure 1.

Overall schematics. Transcriptome data for breast cancer (BRCA) were obtained from the Broad GDAC Firehose database. Following the RNA measurement analysis of a total of 20,531 genes, 1000 genes correlated with CCDC170 were selected (q < 2.0 × 10⁻⁸). Over-representation analysis of the 1000 genes demonstrated a significant relationship with six major cancer-related pathways (p53, ATR/ARM, hedgehog, FOXM1, cell cycle, and Aurora B). Potential gene targets and drug candidates were isolated via drug network analysis using a drug-target database on genes correlated to CCDC170 and the literature review.