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. 2021 Feb 4;13(4):618. doi: 10.3390/cancers13040618

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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miR-224-5p was overexpressed in both urinary EVs and cancer tissues of RCC patients. (A) Top 15 significantly expressed miRNAs in urinary EVs from RCC patients and healthy volunteers (p < 0.01). (B) miR-224-5p levels in cancer and adjacent tissues of RCC samples used in small RNA-sequencing were determined by RT-qPCR. Data are mean ± s.e.m. (C) miR-224-5p expression levels in paired-tissues of RCC patients were determined by RT-qPCR (n = 35). (D) miR-224-5p expression levels in TCGA database (n = 130 for adjacent group; n = 903 for cancer group). * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.