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. Author manuscript; available in PMC: 2021 Feb 27.
Published in final edited form as: Biochemistry. 2020 Apr 24;59(18):1747–1755. doi: 10.1021/acs.biochem.0c00146

Figure 2.

Figure 2.

Bound water in pWNK1 associated with the inactive configuration of hAL. (A) Waters in pWNK1 near helix AL. Cartoon rendering of pWNK1 in magenta (main cartoon) and red (activation loop). Waters are shown in yellow; electron density contoured at 0.8 σ in blue. (B) Cavities are depicted in gray in the same orientation as (A). (C) Waters between hC and β4 and extending from the V-shaped linker (V) into the back of the active site (below and β4 in the orientation shown). (D) Closeup of the cavity near the V-shaped linker and active site. (Surfaces calculated in PyMOL using Cavity_cull default settings).