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. 2021 Feb 26;47(4):64. doi: 10.3892/ijmm.2021.4897

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Copyright: © Katopodis et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Single cell analysis of colon mucosa, using the Single Cell Portal, revealed widespread expression of TMPRSS4. (A) Single-cell transcriptomics data are displayed as a spectral tSNE (T-distributed Stochastic Neighbour Embedding) plot of 366,650 cells, annotated according to known cell types; (B) sub-populations of cell types which are enriched for TMPRSS4 expression, with expression intensity demonstrated by a heat map; (C) single cell analysis using the Single Cell Portal, enriched for population subtypes, represented as violin plots. Notably, high TMPRSS4 expression was noted in immature enterocytes, BEST4-expressing enterocytes and enterocytes. TA1, TA2; transit-amplifying (TA) cells.