Table 1.
Acute toxicity test of HL-003 and amifostine in C57BL/6 mice.
| mg/kg | Survival rate | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 600 | 700 | 800 | 1200 | 1600 | 1800 | 2000 | 2400 | 3200 | |
| Amifostine | 100% (6/6) | 83.33% (5/6) | 66.67% (4/6) | NA | NA | NA | NA | NA | NA |
| HL-003 | NA | NA | NA | 100% (10/10) | 100% (10/10) | 100% (10/10) | 50% (5/10) | 40% (4/10) | 0% (0/10) |
NA: not available. NA indicates that no acute toxicity test was conducted at this dose. (n1/n2): n1 represents the number of surviving mice 14 days postadministration and n2 represents the number of mice in each group preadministration.