Table 3.
PK parameters of HL-003 in SD rats. SD rats (group size, n = 3) received an HL-003 dose of 100 mg/kg i.v. or 400 mg/kg p.o., and blood samples were collected from 0 to 24 h for PK parameter analysis.
| PK parameter | Mean | Standard deviation |
|---|---|---|
| PK parameters of HL-003 in male SD rats after a dose of 100 mg/kg i.v. | ||
| HL_Lambda_z (T1/2, h) | 0.67 | 0.28 |
| C max (ng/mL) | 77510.6 | 2202.1 |
| AUClast (h∗ng/mL) | 30589.1 | 1199.2 |
| AUCINF_pred (h∗ng/mL) | 30606.8 | 1198.3 |
| MRTlast (h) | 0.32 | 0.05 |
| Vz_pred (L/kg) | 3.15 | 1.26 |
| Cl_pred (L/h/kg) | 3.27 | 0.13 |
| Λz calculation time range (h) | NA | NA |
|
| ||
| PK parameters of HL-003 in male SD rats after a dose of 400 mg/kg p.o. | ||
| HL_Lambda_z (T1/2, h) | 6.65 | 2.49 |
| T max (h) | 0.28 | 0.21 |
| C max (ng/mL) | 21580.4 | 8971.2 |
| AUClast (h∗ng/mL) | 51744.1 | 8389.0 |
| AUCINF_pred (h∗ng/mL) | 55842.4 | 6086.6 |
| MRTlast (h) | 5.71 | 0.70 |
| Vz_F_pred (L/kg) | 70.55 | 32.64 |
| Cl_F_pred (L/hr/kg) | 7.22 | 0.82 |
| λz calculation time range (h) | NA | NA |
| F (%) | 42.29 | 6.86 |
NA: not available. NA means that the data has not been calculated.