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. 2021 Feb 19;2021:8875729. doi: 10.1155/2021/8875729

Figure 3.

Figure 3

High-fat diet induces cardiomyocyte hypertrophy and cardiac fibrosis in C57BL/6J mice, which quercetin significantly improves. Representative histological sections of hematoxylin-eosin (HE) staining (a) and wheat germ agglutinin (WGA) staining (b) show cardiomyocyte hypertrophy. Control+vehicle (CV; n = 6 HE; n = 8 WGA), control+quercetin (CQ; n = 6 HE; n = 6 WGA), high-fat+vehicle (HV; n = 6 HE; n = 5 WGA), high-fat+quercetin (HQ; n = 8 HE; n =6 WGA), and representative histological sections of Masson's Trichrome staining and quantification show increased myocardial perivascular (c) and interstitial (d) fibrosis in high-fat diet-fed mice. CV, n = 6; CQ, n = 8; HV, n = 6; HQ, n = 8; Data are mean ± standard deviation. P < 0.05 vs. CV. #P < 0.05 vs. CQ. ^P < 0.05 vs. HV.