Table 2.

Validation for Drive-by Photoscreening; the Validation Statistics Sensitivity, Specificity, Positive Predictive Value (PPV) and ABCD Sensitivity (Sens) and ABCD Specificity (Spec) are Given in the Right-Hand Columns. A 3 x 2 Matrix of Validation Variables includes Conventional A, B, C and D with Additional E (Inconclusive Exam True) and F (Inconclusive Exam Normal). Exam Failure Criteria (Exam Fail?) Include Three Subsets; AAPOS 2003 Refractive Only (Refract Only), Cases with Visual Acuity Defined Amblyopia and/or Constant Strabismus (Strab/Ambly) and the AAPOS 2003 Which Combines Cycloplegic Refraction Guideline Levels Plus Strabismus Plus Amblyopia. There are Three Levels of Instrument Referral Criteria for plusoptiX and 2WIN Shown in Table 1 Offering Sensitive (Sens), Baseline (Refer) and Specific (Spec) Screen Interpretations

Drive-By Photoscreen				Exam+	Exam-
			refer	A	B
			pass	C	D
			inconclusive	E	F	i=E+F				A/(A+C)	D/(B+D)	A/(A+B)	A/(A+C+i)	D/(B+D+i)
maker	model	Exam Fail?	criteria	A	B	C	D	E	F	sensitivity	specificity	PPV	ABCD-sens	ABCD-spec
plusoptiX	S12	AAPOS 03	sens	43	4	6	21	12	2	88%	84%	91%	68%	54%
		AAPOS 03	refer	41	1	7	25	12	2	85%	96%	98%	66%	63%
		AAPOS 03	spec	34	0	14	26	12	2	71%	100%	100%	55%	65%
		strab-ambly	refer	17	24	3	30	6	8	85%	56%	41%	50%	44%
		refract only	refer	41	1	5	27	11	3	89%	96%	98%	68%	64%
Adaptica	2WIN	AAPOS 03	sens	51	5	6	22	3	1	89%	81%	91%	84%	71%
	Kaleidos	AAPOS 03	refer	44	3	12	25	3	1	79%	89%	94%	73%	78%
		AAPOS 03	spec	38	3	19	24	3	1	67%	89%	93%	62%	77%
		strab-ambly	refer	21	27	5	31	1	3	81%	53%	44%	70%	50%
		refract only	refer	44	4	10	26	3	1	81%	87%	92%	76%	76%
Rebion	blinq	AAPOS 03	refer	23	7	31	20	7	0	43%	74%	77%	38%	59%
		strab-ambly	refer	13	17	11	40	3	4	54%	70%	43%	42%	63%
		refract only	refer	21	9	29	2	7	0	42%	18%	70%	37%	11%