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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Kidney Int. 2020 Nov 1;99(3):620–631. doi: 10.1016/j.kint.2020.09.031

Figure 8. Tubulointerstitial injury improvement lessened subsequent renal response to LMB2 injury.

Figure 8.

Body weight, a measure of edema related to marked proteinuria, was less at day 10 after podocyte injury in when DMOG was added (A). Renal function, assessed by BUN and Scr, was worse in folic acid versus vehicle mice, and BUN was decreased after DMOG intervention (B). Ex vivo bioluminescence images confirmed decreased collagen I mRNA signal in folic acid +DMOG+LMB2 versus folic acid+LMB2 mice (C). In vivo bioluminescence images showed lessened collagen I mRNA signal when DMOG was added to mice with combined folic acid and podocyte injury (D).