Table 3:

OCPs reduce prefrontal cortical thickness.In every prefrontal cortical subregion tested, in both hemispheres, thickness measurements were smaller during the OCP arm compared to placebo.

	Left hemisphere: OCPs vs placebo p-value (direction of effect); Cohen’s d	Right hemisphere: OCPs vs placebo p-value (direction of effect); Cohen’s d
Prefrontal cortical subregion
caudal middle frontal	0.52 (OCP < Placebo); 0.00	0.11 (OCP < Placebo); 0.08
pars opercularis	0.84 (Placebo < OCP); 0.07	0.008 (OCP < Placebo)‡; 0.30
pars orbitalis	0.13 (OCP < Placebo); 0.37	0.24 (OCP < Placebo); 0.15
pars triangularis	0.01 (OCP < Placebo) ‡; 0.37	0.001 (OCP < Placebo) Benjamini-Hochberg adjusted p-value = 0.018*; 0.26
rostral middle frontal	0.33 (OCP < Placebo); 0.16	0.15 (OCP < Placebo); 0.09
superior frontal	0.31 (OCP < Placebo); 0.03	0.26 (OCP < Placebo); 0.10
frontal pole	0.75 (OCP < Placebo); 0.04	0.03 (OCP < Placebo) ‡; 0.31
lateral orbitofrontal	0.09 (OCP < Placebo); 0.41	0.87 (OCP < Placebo); 0.11
medial orbitofrontal	0.80 (Placebo < OCP); 0.01	0.11 (OCP < Placebo); 0.30

^‡This difference reached statistical significance, at α = 0.05, in the right pars opercularis, bilateral pars triangularis, and right frontal pole.

^*The effect in the right pars triangularis survived correction for multiple comparisons using the Benjamini-Hochberg false discovery rate adjustment.