Figure 2.
NGS methods in DNA methylation profiling. Affinity-based enrichment methods: MeDIP-Seq: methylated DNA immunoprecipitation sequencing, MBD-Seq: methyl-CpG binding domain sequencing; Busulfite conversion-based methods: RRBS-Seq: reduced representation bisulfite sequencing, WGBS: whole-genome bisulfite sequencing.