Table 1.
Clinical features of the rheumatoid arthritis patients at the time of recruitment, by oxylipin cluster*
| Cluster I (n = 23) |
Cluster II (n = 37) |
|
|---|---|---|
| Clinical features | ||
| Duration of symptoms, weeks | 24.00 (11.50–37.00) | 20.00 (8.50–30.00) |
| Morning stiffness, minutes | 60.00 (15.00–90.00) | 30.00 (12.50–120.00) |
| Tender joint count (of 28 joints) | 9.00 (6.00–14.00) | 8.00 (4.50–13.00) |
| Swollen joint count (of 28 joints) | 6.00 (3.00–10.00) | 5.00 (3.00–8.50) |
| ESR, mm/hour | 19.00 (11.00–37.00) | 20.00 (7.50–34.00) |
| CRP, mg/dl | 0.80 (0.30–3.20) | 0.60 (0.20–1.65) |
| Patient global assessment (0–100 VAS) | 70.00 (60.00–90.00) | 50.00 (40.00–72.50)† |
| Patient pain assessment (0–10 VAS) | 8.00 (7.00–8.00) | 6.00 (5.00–8.00)‡ |
| DAS28 (scale 0–10) | 5.66 (4.68–6.45) | 5.05 (3.86–6.07) |
| SDAI (scale 0–86) | 29.60 (23.12–39.37) | 26.30 (18.15–35.05) |
| HAQ (scale 0–3) | 1.50 (1.66–0.65) | 1.10 (0.60–1.65) |
| Fatigue (0–10 VAS) | 5.00 (0.00–8.00) | 6.00 (1.50–8.00) |
| RF+, no. (%) | 16 (69.5) | 21 (56.7) |
| ACPA+, no. (%) | 15 (65.2) | 20 (54.0) |
| RF−/ACPA−, no. (%) | 5 (21.7) | 14 (37.8) |
| Traditional CV risk factors, no. (%) | ||
| Hypertension | 9 (39.1) | 12 (32.4) |
| Diabetes | 3 (13.0) | 4 (10.8) |
| Dyslipidemia | 8 (34.7) | 11 (29.7) |
| Smoking | 6 (26.0) | 17 (45.9) |
| Treatments, no. (%) | ||
| None§ | 18 (78.2) | 32 (86.4) |
| Glucocorticoids | 4 (17.3) | 4 (10.8) |
| Methotrexate | 2 (8.6) | 3 (8.1) |
Except where indicated otherwise, values are the median (interquartile range). Differences were assessed by Mann-Whitney U or chi-square test (or Fisher’s exact test, as appropriate), according to the distribution of the variables; other than those indicated by footnotes, all P values between cluster I and cluster II were nonsignificant at P < 0.05. ESR = erythrocyte sedimentation rate; CRP = C-reactive protein; VAS = visual analog scale; DAS28 = Disease Activity Score in 28 joints; SDAI = Simplified Disease Activity Index; HAQ = Health Assessment Questionnaire; RF+ = rheumatoid factor-positive; ACPA+ = anti–citrullinated protein antibody–positive; CV = cardiovascular.
P = 0.016 versus cluster I.
P = 0.003 versus cluster I.
Among the patients with early rheumatoid arthritis, 50 were recruited before being exposed to any treatment (designated treatment-naive).