Skip to main content
. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Trends Immunol. 2021 Feb 13;42(3):228–247. doi: 10.1016/j.it.2021.01.005

Figure 3. Human Transcriptomic Marker Genes Characterizing Homeostatic and Reactive Glial Subtypes.

Figure 3.

Cartoon lists homeostatic (left) versus reactive (right) glial subtype signature genes by means of volcano plot visualization. Marker genes were selected by their specific enrichment in microglia, oligodendrocyte (OL) precursor, and myelinating cells, as well as astrocytes based on recent single-cell/nucleus RNA-sequencing (sc/snRNA-seq) studies from human control and multiple sclerosis (MS) tissues. See Boxes 2-4 in the main text for details about signature genes and their functional relevance. Note color spectrum on the bottom illustrates dynamic changes in gene expression between homeostatic and reactive glial subtypes according to cell type color code. This figure was created using BioRender (https://biorender.com/).