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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Kidney Int. 2020 Nov 4;99(3):598–608. doi: 10.1016/j.kint.2020.10.024

Figure 4. HBEGF has FGF23-like activity during low phosphate diet.

Figure 4.

Six-week old WT female mice were placed on a phosphate (Pi) deficient diet (0.02% phosphorus, ‘LoP’) for 1-week and given one dose of rhHBEGF or saline for 1 hour. Low-Pi mice had significantly lowered circulating (A) iFGF23. With rhHBEGF administration, (B) Egr1 increased (180-fold, P<0.01), (C) Cyp24a1 mRNA was elevated 5-fold (P<0.01) and (D) baseline elevated Cyp27b1 mRNA was reduced to 63% compared to saline-injected mice (P<0.05) (**P<0.01 versus control diet saline injection mice. #P<0.05, ##P<0.01 versus HBEGF treatment within the same diet group. N=5. ‘Sal’, saline. ‘LoP’, low phosphate diet).