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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Trends Mol Med. 2020 Nov 5;27(3):280–292. doi: 10.1016/j.molmed.2020.10.003

Figure 2: Nephrogenesis and Renin Expression.

Figure 2:

A) Illustration of the two structures that give rise to the nephron in adult animals: the metanephric mesenchyme (MM) and the ureteric bud (UB) at E11. B) Reciprocal interaction of the MM and UB results in the growth of the UB towards the MM which begins to coalesce and continues through a series of progressive structures – namely a vesicle, comma and s-shaped body – before forming the tubular system and stromal compartment. Expression of key marker genes such as Foxd1 in the stromal cells and Hoxb7 in the collecting duct progenitors of the UB becomes detectable. C) By E19, the glomerulus is fully formed, and renin expression can be seen widely in the afferent arterioles and broader vasculature. D) During adulthood, expression of renin recedes to the JGA and those cells which expressed renin differentiate into vascular smooth muscle cells, pericytes and mesangial cells.