Table 2.
Nicotine delivery and number of puffs taken from own brand cigarette, Juul EU and Juul US (N = 18)
| Product | Median no. of puffs (IQR) | Median Cmax (IQR) |
Median Tmax
a (IQR) |
Mean AUC0 ≥ 30
a (SD), N = 14 b |
|---|---|---|---|---|
| Cigarette |
13.5 (10.8–17.3) |
12.9 (8.0–35.6) |
5 (4–8) | 324.8 (208.9) |
| Juul EU |
15.5 (12.8–21.3) |
3.8 (2.5–7.5) |
6 (4–8) | 77.3 (31.0) |
| Juul US |
14.5 (10.0–21.5) |
21.1 (9.9–36.3) |
4 (2–6) | 355.9 (173.7) |
| Difference between Juul EU and the other productsc |
Juul US: z = −0.76, p = 0.447 Cigarette: z = −1.83, p = 0.067 |
Juul US: z = −3.59, p < .001 Cigarette: z = −3.64, p < .001 |
Juul US: z = −1.82, p = 0.068 Cigarette: z = −0.52, p = 0.605 |
Juul US: t(13) = −6.40, p < .001 Cigarette: t(13) = −4.64, p < .001 |
aMedian Tmax values and mean AUC0 ≥ 30 values that were used to compare products statistically differ slightly from values in Fig. 1estimated by PK Solver because the comparisons used means across individuals whereas PK Solver calculates means across time-points
bAUC0 ≥ 30 could not be calculated for four participants as the 30 min blood sample could not be collected
cSignificance threshold set at 0.025 due to multiple testing