Table 4.
Nicotine delivery and number of puffs taken from Juul EU, refillable and cig-a-like ECs (N = 7)
| Product | Median no. of puffs (IQR) | Mean Cmax (SD) |
Mean Tmaxa (SD) |
Median AUC0 ≥ 30a (IQR), N = 6b |
|---|---|---|---|---|
| Juul EU | 13.0 (11.0–16.0) | 5.5 (3.4) | 5.4 (2.5) | 89.8 (71.4–106.9) |
| Refillable EC | 14.5 (13.5–19.0) | 10.5 (5.3) | 10.0 (8.9) | 203.2 (165.7–268.9) |
| Cig-a-like EC | 15.8 (14.6–22.4) | 8.0 (3.8) | 8.1 (5.5) | 136.6 (93.5–188.9) |
| Difference between Juul EU and the other productsc |
Refillable: z = −0.51, p = 0.611 Cig-a-like: z = −1.52, p = 0.128 |
Refillable: t(6) = 3.02, p = 0.023 Cig-a-like: t(6) = 2.49, p = 0.047 |
Refillable: t(6) = 1.30, p = 0.241 Cig-a-like: t(6) = 1.20, p = 0.275 |
Refillable: z = −2.20, p = 0.028 Cig-a-like: z = −1.99, p = 0.046 |
aMedian Tmax values and mean AUC0 ≥ 30 values that were used to compare products statistically differ slightly from values in Fig. 3estimated by PK Solver because the comparisons used means across individuals whereas PK Solver calculates means across time-points
bAUC0 ≥ 30 could not be calculated for one participant as the 30 min blood sample could not be collected
cSignificance threshold set at 0.025 due to multiple testing