Table 1.
Cohen’s kappa coefficient test for clinical outcome between sibling pairs (total 28 pairs of siblings from 25 families (MSKCC-CCHMC cohort).
| Variable | Kappa | 95% Confidence Interval |
Level of Agreement |
Frequency of event (%) |
|---|---|---|---|---|
| Any congenital anomalies | 0.14 | (−0.15, 0.43) | None | 73.58 |
| Radial abnormalities | 0.16 | (−0.24, 0.56) | None | 13.21 |
| Thumb abnormalities | 0.32 | (−0.03, 0.67) | Minimal | 37.74 |
| Other skeletal abnormalities | 0.51 | (0.03, 0.99) | Weak | 11.32 |
| Kidney abnormalities | 0.65 | (0.34, 0.96) | Moderate | 28.3 |
| Cardiac abnormalities | 0.35 | (−0.08, 0.78) | Minimal | 15.09 |
| Microcephaly | 0.76 | (0.44, 1.00) | Moderate | 16.98 |
| Low birth weight | 0.48 | (0.12, 0.83) | Weak | 26.42 |
| Tracheo-oesophageal fistula | 0.46 | (−0.17, 1.00) | Weak | 7.55 |
| Anal atresia | 0.34 | (−0.23, 0.92) | Minimal | 9.43 |
| Short stature | 0.23 | (−0.11, 0.57) | Minimal | 43.4 |
| Growth retardation | 0.44 | (0.09, 0.80) | Weak | 22.64 |
| Learning disability | 0.47 | (−0.13, 1.00) | Weak | 5.77 |
| MDS | 0.03 | (−0.34, 0.41) | None | 18.87 |
| AML | −0.05 | (−0.12, 0.02) | None | 5.66 |