Table 3.
Agreement between HAQ-DI based MDA and PROMIS-PF based MDA in subgroups defined by Physical Function ability across all visits
| Agreement in subgroups* | HAQ-DI MDA & PROMIS-PF4a MDA | HAQ-DI MDA & PROMIS-PF CAT MDA | HAQ-DI VLDA & PROMIS-PF4a VLDA | HAQ-DI VLDA & PROMIS-PF CAT VLDA |
|---|---|---|---|---|
| HAQ-DI≤0.5, less/no disability | ||||
| Kappa 95% CI N |
0.86 (0.77-0.93) 184 |
0.94 (0.88-0.99) 186 |
0.84 (0.78-0.90) 159 |
0.93 (0.88-0.97) 160 |
| HAQ-DI > 0.5, more disability | ||||
| Kappa 95% CI N |
0.76 (0.53-0.95) 116 |
0.76 (0.53-0.95) 116 |
0.80 (0.71-0.88) 116 |
0.70 (0.60-0.79) 116 |
| PROMIS-PF 4a T-score ≥41.3, better physical function ability | ||||
| Kappa 95% CI N |
0.93 (0.85-0.98) 182 |
0.93 (0.85-0.98) 182 |
0.86 (0.79-0.91) 157 |
0.86 (0.79-0.91) 157 |
| PROMIS-PF 4a T-score < 41.3, worse physical function ability | ||||
| Kappa 95% CI N |
0.55 (0.31-0.78) 118 |
0.86 (0.70-0.97) 120 |
0.78 (0.70-0.86) 118 |
0.81 (0.72-0.88) 118 |
| PROMIS-PF CAT T-score ≥41.3, better physical function ability | ||||
| Kappa 95% CI N |
0.87 (0.79-0.94) 203 |
0.94 (0.88-0.99) 205 |
0.80 (0.73-0.87) 177 |
0.81 (0.74-0.87) 178 |
| PROMIS-PF CAT T-score < 41.3, less physical function ability | ||||
| Kappa 95% CI N |
0.65 (0.17-0.92) 98 |
0.65 (0.17-0.92) 98 |
0.88 (0.80-0.95) 98 |
0.88 (0.79-0.94) 98 |
Bias corrected 95% confidence intervals for the kappa statistic were calculated using bootstrapping with 2000 repetitions of individual patients.
Abbreviations
CI: Confidence interval; HAQ-DI: Heath Assessment Questionnaire-Disability Index; PROMIS-PF 4a: Patient Reported Outcomes Measurement Information System Short Form v2.0 Physical Function 4a; PROMIS-PF CAT: PROMIS Bank v1.2 - Physical Function Computer Adaptive Test; MDA: HAQ-DI Minimal disease activity that includes the HAQ-DI ≤0.5 criterion; MDA PROMIS-PF4a includes the PROMIS-PF4a T-score ≥41.3 criterion; MDA PROMIS-PF Bank includes the PROMIS-PF CAT T-score ≥41.3 criterion; VLDA HAQ-DI: Very low disease activity that includes the HAQ-DI ≤0.5 criterion; VLDA PROMIS-PF4a includes the PROMIS-PF4a T-score ≥41.3 criterion; VLDA PROMIS-PF CAT includes the PROMIS-PF CAT T-score ≥41.3 criterion.