Table 5.
Longitudinal agreement between HAQ-DI based MDA and corresponding PROMIS-PF based MDA state changes
| Agreement* | V1 - V2 | V2 - V3 | V3 - V4 | |
|---|---|---|---|---|
| MDA HAQ-DI state change with MDA PROMIS-PF4a state change |
Kappa 95% CI N |
0.75 (0.47-0.95) 71 |
0.84 (0.58-1.00) 67 |
0.72 (0.37-0.94) 51 |
| MDA HAQ-DI state change with MDA PROMIS-PF CAT state change |
Kappa 95% CI N |
0.81 (0.49-1.00) 72 |
0.94 (0.75-1.00) 68 |
0.84 (0.48-1.00) 52 |
| VLDA HAQ-DI state change with VLDA PROMIS-PF4a state change |
Kappa 95% CI N |
0.75 (0.44-0.95) 59 |
0.84 (0.51-1.00) 57 |
- - 47 |
| VLDA HAQ-DI state change with VLDA PROMIS-PF CAT state change |
Kappa 95% CI N |
0.82 (0.55-1.00) 60 |
0.92 (0.64-1.00) 58 |
- - 47 |
MDA (or VLDA) state changes were defined as transitions in corresponding MDA (or VLDA) state between consecutive visits, for example V1-V2 represents agreement between transitions in MDA (or VLDA) HAQ-DI state from visit 1 to visit 2 with transitions in each MDA (or VLDA) PROMIS-PF state from visit 1 to visit 2. Bias corrected 95% confidence intervals for the kappa statistic were calculated using bootstrapping with 2000 repetitions of individual patients. When sample size was less than 50, kappa and 95% CI were not calculated, designated with “-“.
Abbreviations
CI: confidence interval; N: available observations; HAQ-DI: Heath Assessment Questionnaire-Disability Index; PROMIS-PF 4a: Patient Reported Outcomes Measurement Information System Short Form v2.0 Physical Function 4a; PROMIS-PF CAT: PROMIS Bank v1.2 – Physical Function Computer Adaptive Test; MDA HAQ-DI: Minimal disease activity that includes the HAQ-DI ≤0.5 criterion; MDA PROMIS-PF4a includes the PROMIS-PF4a T-score ≥41.3 criterion; MDA PROMIS-PF CAT includes the PROMIS-PF CAT T-score ≥41.3 criterion; VLDA HAQ-DI: Very low disease activity includes the HAQ-DI ≤0.5 criterion; VLDA PROMIS-PF4a includes the PROMIS-PF4a T-score ≥41.3 criterion; VLDA PROMIS-PF CAT includes the PROMIS-PF CAT T-score ≥41.3 criterion.