Table 2.
Change of the body weight of rats, main organ weights and organ/body weights of rats in sub-chronic toxicity
| Groups | NC | T1 | T2 | T3 | NC | T1 | T2 | T3 |
|---|---|---|---|---|---|---|---|---|
| Female | Male | |||||||
| Initial weight (g) | 69.31 ± 5.22 | 69.46 ± 5.76 | 69.43 ± 4.45 | 69.72 ± 4.43 | 72.56 ± 8.12 | 72.78 ± 7.85 | 72.87 ± 7.48 | 72.56 ± 7.37 |
| 1 week weight (g) | 101.40 ± 7.71 | 101.14 ± 7.22 | 100.25 ± 10.03 | 101.23 ± 7.58 | 109.02 ± 12.32 | 107.13 ± 13.33 | 106.78 ± 16.64 | 102.87 ± 13.08 |
| 3 week weight (g) | 171.02 ± 12.24 | 171.12 ± 7.43 | 171.81 ± 10.24 | 163.45 ± 10.89 | 235.67 ± 13.72 | 218.24 ± 22.86 | 223.78 ± 19.02 | 214.45 ± 17.32 |
| 5 week weight (g) | 216.67 ± 16.12 | 211.90 ± 11.12 | 210.36 ± 13.14 | 205.22 ± 10.93 | 342.90 ± 13.92 | 326.78 ± 21.45 | 335.13 ± 21.83 | 328.67 ± 12.16 |
| 7 week weight (g) | 255.04 ± 16.21 | 247.48 ± 13.92 | 248.22 ± 17.06 | 239.93 ± 15.94 | 423.67 ± 15.03 | 403.67 ± 26.68 | 410.14 ± 25.08 | 398.67 ± 14.87 |
| 9 week weight (g) | 278.38 ± 15.42 | 268.32 ± 12.14 | 270.92 ± 16.34 | 260.67 ± 17.44 | 453.83 ± 14.58 | 451.78 ± 29.82 | 457.78 ± 22.42 | 446.58 ± 15.28 |
| 11 week weight (g) | 298.23 ± 23.04 | 283.52 ± 12.33 | 286.58 ± 15.12 | 276.72 ± 17.53 | 515.33 ± 23.48 | 496.54 ± 34.30 | 506.88 ± 25.03 | 495.58 ± 6.78 |
| 13 week weight (g) | 312.45 ± 24.82 | 308.91 ± 9.30 | 302.46 ± 13.78 | 292.34 ± 17.25 | 542.80 ± 26.14 | 518.91 ± 35.42 | 527.08 ± 28.58 | 520.32 ± 5.71 |
| Weight gain (g) | 243.14 ± 19.60 | 239.55 ± 3.54 | 233.38 ± 9.33 | 222.62 ± 12.82 | 470.24 ± 18.02 | 446.13 ± 27.57 | 454.21 ± 21.10 | 446.76 ± 8.34 |
| Liver weight (g) | 7.94 ± 0.66 | 7.42 ± 0.45 | 7.65 ± 0.42 | 7.47 ± 0.70 | 14.05 ± 1.44 | 13.87 ± 1.54 | 14.01 ± 1.33 | 13.10 ± 1.26 |
| Spleen weight (g) | 0.56 ± 0.09 | 0.59 ± 0.06 | 0.62 ± 0.09 | 0.57 ± 0.10 | 1.03 ± 0.12 | 1.01 ± 0.22 | 0.97 ± 0.15 | 0.89 ± 0.15 |
| Kidney weight (g) | 1.90 ± 0.13 | 1.87 ± 0.09 | 1.87 ± 0.14 | 1.81 ± 0.15 | 3.40 ± 0.41 | 3.25 ± 0.43 | 3.19 ± 0.12 | 2.99 ± 0.32 |
| Testis weight (g) | – | – | – | – | 3.76 ± 0.34 | 3.63 ± 0.29 | 3.86 ± 0.23 | 3.60 ± 0.36 |
| Liver/bw (%) | 2.55 ± 0.18 | 2.40 ± 0.17 | 2.54 ± 0.11 | 2.56 ± 0.17 | 2.59 ± 0.31 | 2.67 ± 0.25 | 2.66 ± 0.18 | 2.52 ± 0.24 |
| Spleen/bw (%) | 0.18 ± 0.03 | 0.19 ± 0.02 | 0.20 ± 0.04 | 0.20 ± 0.03 | 0.19 ± 0.03 | 0.19 ± 0.04 | 0.18 ± 0.02 | 0.17 ± 0.03 |
| Kidey/bw (%) | 0.61 ± 0.05 | 0.61 ± 0.04 | 0.62 ± 0.03 | 0.62 ± 0.04 | 0.63 ± 0.08 | 0.63 ± 0.08 | 0.61 ± 0.04 | 0.58 ± 0.06 |
| Testis/bw (%) | – | – | – | – | 0.69 ± 0.06 | 0.70 ± 0.04 | 0.73 ± 0.05 | 0.69 ± 0.07 |
NC mice without FSLT, T1 mice treated with 1.25 mg/g·bw, T2 mice treated with 2.5 mg/g·bw, T3 mice treated with 5.0 mg/g·bw. Compared with NC, *P < 0.05,**P < 0.01