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. 2021 Feb 13;5(3):256–274. doi: 10.7150/ntno.51676

Figure 4.

Figure 4

Schematic representation of different EV radiolabelling methods. A) Surface radiolabelling: radionuclide can be incorporated into the EV membrane directly or via a chelator. B) Intraluminal radiolabelling: ionophores allow radionuclides to be transported across the lipid membrane where they can be trapped as their lipophilicity changes or bind to metal chelating biomolecules.