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. 2021 Jan 22;11(8):3580–3594. doi: 10.7150/thno.55441

Figure 2.

Figure 2

Oxygeneration performance of CV@CaP to enhance RT efficiency in vitro. (A) Oxygen production curves of water, CV and CV@CaP over time (5 hours). (B) Cytotoxicity of CV and CV@CaP to breast cancer cell line 4T1. (C) The process (top) of CV@CaP modulating cell hypoxia by photosynthesis, and fluorescence images (bottom) showing the alleviation of hypoxia in the 4T1 tumor cells treated with CV@CaP. Cells and hypoxia signals were stained with DAPI (blue) and hypoxyprobe (red), respectively. Scale Bar = 100 µm. (D) Colony formation assay and (E) Survival curves of 4T1 cells treated with or without CV@CaP under X-ray irradiation (0 to 8 Gy). (F) Cell migration assay and (G) corresponding quantitative analysis of 4T1 cells treated with or without CV@CaP under X-ray irradiation (0 and 6 Gy). **p < 0.01, ***p < 0.001.