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EGFR-TKI-resistant cell lines and tissues possess elevated DR4 expression. A, The basal levels of DR4 in the indicated cell lines were detected with Western blotting. B-E, DR4 in human NSCLC tissues with EGFR mutations was detected with IHC. Representative cases in which DR4 expression was increased post relapse from EGFR-TKI treatment are presented in B. Quantitation of DR4 expression for all relapsed cases is presented in C-E. Pt, patient.
