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. 2021 Jan 26;11(8):3676–3693. doi: 10.7150/thno.55424

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METTL14 deficiency promoted RCC metastasis in vitro and in vivo and correlated with EMT processes. (A) Western blot of METTL14 knockout efficiency in 786-O cells. (B-E) Wound healing, migration, and invasion assays of WT and METTL14^-/- (M14-KO#1 and M14-KO#2) 786-O cells and WT and METTL14-overexpressing (M14-OE) ACHN cells. (F-H) In vivo BLI, white-light images of excised lungs, and H&E staining of a metastasis model generated with WT and METTL14^-/- Luc-786-O cells. (I-J) In vivo BLI and H&E staining of a metastasis model generated with WT and M14-OE Luc-ACHN cells. (K) Western blots of the protein expressions of METTL14 and EMT markers in the RCC cell lines. (L-M) Representative IHC staining and correlation analyses of METTL14 and EMT markers in RCC samples.