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. 2021 Feb 7;22(4):1666. doi: 10.3390/ijms22041666

Figure 6.

Figure 6

Excitatory synaptic properties of putative VTA dopamine neurons are not changed by PCE in female preadolescent offspring. (a) Dopamine cells from PCE (ncells: 30, nrats: 11/group) offspring exhibit an increased paired-pulse ratio (EPSC2/EPSC1) of AMPA EPSCs compared to CTRL (ncells: 15, nrats: 7/group) group. The left-hand panel shows representative traces of paired AMPA EPSCs recorded from VTA putative dopamine neurons of CTRL and PCE offspring. Calibration bar: 25 ms, 50 pA. (b) PCE effects on 1/CV2 values (PCE ncells: 20, CTRL ncells: 7). (c) Current–voltage relationship (I–V) curves of AMPA EPSCs recorded from dopamine neurons in PCE (ncells: 10, nrats: 12/group) and CTRL (ncells: 8, nrats: 8/group) offspring. Data are represented as mean ± s.e.m. AMPA EPSCs traces recorded at −70 mV, 0 mV, and +40 mV from CTRL and PCE rats are shown on the left. Calibration bar: 10 ms, 25 pA. (d) The AMPA/NMDA ratio is not affected by PCE. The left-hand panel shows representative traces of AMPA and NMDA EPSCs traces recorded from dopamine neurons held at +40 mV in slices from PCE (ncells: 9, nrats: 9/group) and CTRL (ncells: 9, nrats: 7/group) offspring. Calibration bar: 10 ms, 50 pA. Unless otherwise specified, all data are represented as box-and-whisker plots with single values (min to max). *, p < 0.05.