Table 4.
Cell signaling Pathways with the related genes in STUMP4 and its recurrence LMS1.
| Cell Signaling Pathway | Genes with a Significant GOterm | Unmethylated Genes in STUMP4 (Methylated in LMS1) |
Methylated Genes in STUMP4 (Unmethylated in LMS1) |
|---|---|---|---|
| NFKβ cascade | 22 | NDFIP1, MAP3K7IP2, PLK2, NDFIP2, NLRC3, PPM1A, SECTM1, TRIM13, IRAK1, TSPAN6, VAPA, TNFAIP3, BIRK2, C9orf89, EDG2, GOLT1B, LTBR, PRDX3, TNFRSF1A, RPS6KB2 | ZDHHC13, TFG |
| WNT receptor signaling pathway | 16 | CSNK2B, LRRFIP2, PYGO2, PORCN, DKK1, FZD3, FZD6, FZD8, HBP1, WNT10A, WNT2B, WNT6, WNT7A, DIXDC1, TLE4, WNT11 | / |
| Smoothened signaling pathway (Hedgehog signaling pathway) | 1 | CTNNA1 | / |
| Negative regulation of WNT pathway | 1 | FRZB | / |
| Regulation ARF GTPase activity (Ras protein transduction) | 24 | ARGEF2, PSD3, CENTB2, CENTD1, GNB1, DOK3, EVI5, PSD4, RASSF1, RASSF6, GBF1, DDEF1, DOK2, SMAP1, PSCD1, PSCD4, ARFGEF1, CTGLF4 | ARFGAP1, FBXO8, IQSEC1, TBC1D22A, TBC1D15, TBC1D16 |
| Ras GTPase activity | 15 | TBC1D5, TBC1D8, TBC1D9, TBC1D9B, TBC1D2B, TBC1D4, EVI5L, SGSM1, TBC1D10A, TBC1D20, TBC1D25, TBC1D10C, TBC1D12, CENTG1, RABGAP1 | / |