Table 1.
Metabolic and hormonal parameters of experimental groups at week 12.
| RD (n = 20) |
HFD (n = 19) |
P HFD vs. RD |
HFD + T (n = 18) |
P HFD + T vs. RD |
P HFD + T vs. HFD |
|
|---|---|---|---|---|---|---|
| Total body weight (g) | 3890.5 (3753.5–3988.2) |
3733.0 (3479.7–3861.2) |
0.058 | 3788.0 (3506.5–4174.2) |
0.558 | 0.548 |
| Blood glucose (g/L) | 0.95 (0.82–1.13) |
1.82 (1.59–2.24) |
<0.0001 | 1.49 (1.06–1.74) |
0.001 | 0.002 |
| OGTT (iAUC) | 121.1 (98.8–157.8) |
207.0 (187.2–221.9) |
<0.0001 | 182.0 (170.2–229.0) |
0.001 | 0.064 |
| Cholesterol (mg/dL) | 48.0 (29.0–49.0) |
1464.0 (872.5–2,370.0) |
<0.0001 | 1167.0 (769.5–1317.2) |
<0.0001 | 0.095 |
| Triglycerides (mg/dL) | 65.0 (43.5–75.0) |
168.0 (114.0–256.0) |
<0.0001 | 137.0 (83.0–344.5) |
0.001 | 0.504 |
| MAP (mmHg) | 85.0 (70.0–98.7) |
150.0 (131.2–165.0) |
<0.0001 | 113.1 (106.2–122.7) |
<0.0001 | <0.0001 |
| VAT (% of total weight) | 0.95 (0.83–1.10) |
1.11 (0.93–1.22) |
0.011 | 0.13 (0.07–0.25) |
<0.0001 | <0.0001 |
| T (nmoles/L) | 6.72 (4.42–11.10) |
0.70 (0.69–1.19) |
<0.0001 | 19.75 (9.68–39.40) |
0.001 | <0.0001 |
| LH (ng/mL) | 0.33 (0.12–0.65) |
0.06 (0.05–0.14) |
0.004 | 0.06 (0.04–0.10) |
<0.0001 | 0.389 |
| Prostate weight (% of total weight) | 0.016 (0.012–0.021) |
0.009 (0.007–0.013) |
0.001 | 0.027 (0.021–0.029) |
<0.0001 | <0.0001 |
| Seminal vesicle weight (% of total weight) | 0.014 (0.011–0.021) |
0.013 (0.011–0.016) |
0.595 | 0.055 (0.043–0.064) |
<0.0001 | <0.0001 |
Results are reported as medians with quartiles in brackets. Bold text for p value indicates a statistically significant difference. RD = regular diet; HFD = high-fat diet; OGTT = oral glucose tolerance test; iAUC = incremental area under the curve of OGTT; MAP = mean arterial pressure; VAT = visceral adipose tissue; T = testosterone; LH = luteinizing hormone.