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. 2021 Feb 6;9(2):159. doi: 10.3390/biomedicines9020159

Figure 4.

Figure 4

Cell signaling pathways involved in hepatocellular carcinoma progression. Proteomic biomarkers act through MAPK, Wnt/β-catenin, PI3K-Akt, JAK/STAT, and TGF-β/SMAD signaling pathways for cell proliferation, survival, migration and invasion, induction of epithelial-to-mesenchymal transition, angio- and vasculogenesis, inflammation, and tumor microenvironment remodeling. Regulation of a biomarker expression by non-coding RNAs and changes in gene expression signatures are shown.