AAV	Adeno-associated virus
Ac-CMV-GFP	ArecombinantBaculovirusVector expression GFP
AF	Annulus Fibrosus
AP-2α	ActivatorProtein-2α
BMP	BoneMorphogeneticProtein
CASFISH	Cas9-mediated Fluorescence In situ Hybridization
CRISPR	Clustered Regulatory Interspaced Short Palindromic Repeats
CRISPRi	CRISPR interference
CRISPRa	CRISPR activation
crRNA	CRISPR RNA
DRG	DorsalRootGanglion
ECM	Extracellular matrix
GDF	GrowthDifferentiationFactor
GFP	GreenFluorescenceProtein
HDR	Homology directed repair
IGF-1	Insulin-likeGrowthFactor-1
IL	Interleukin
IL‑1β	Interleukin-1β
IL‑1α	Interleukin-1α
IVD	Intervertebral disc
IVDD	Intervertebral disc degeneration
LBP	LowBackPain
MCBC	MixedCationicBlockCopolymers
miRNA	MicroRNA
MMP	MatrixMetalloproteinase
MRI	Magnetic Resonance Imaging
RNAi	RNA Interference
MSCs	Mesenchymal stem cells
mTOR	Mechanistic target of rapamycin
mTORC1	mTOR complex 1
NHEJ	Non-homologous end joining
NP	Nucleus pulposus
SASP	Senescence-AssociatedSecretoryPhenotype
PG	Proteoglycan
P-GSK-3β	phosphorylated glycogen synthase kinase-3 β
PI3K	Phospoinositide3-Kinase
P-mTOR	Phosphorylated-mTOR
PSSS	PostSpinalSurgerySyndrome
RAPTOR	Regulatory-associated protein with mTOR
RICTOR	Rapamycin-insensitive companion of mTOR
RSV	Resveratrol
sgRNA	Single-guide RNA
Sox	SRY-Boxtranscriptionfactor
TGF-β	Transforming growth factor-β
TLR4	Toll-likeReceptor4
TNF‑α	TumorNecrosisFactor- α
trRNA	trans-activating crRNA (tracrRNA)
UTMD	Ultrasound-targeted microbubble destruction
VP	ViralParticle