Figure 1.

Enhancement of plasminogen activation on the cell surface. Activation of cell-associated plasminogen (Plg) to plasmin (Pm) by cell-associated plasminogen activators (PA) is markedly enhanced compared to the reaction in solution. The Pm formed remains on the cell surface, where it is relatively protected from its inhibitor, α₂-antiplasmin (α₂-AP). This results in the association of the proteolytic activity of plasmin with the cell surface to function in fibrinolysis. This figure is modified from a figure originally published in © 2012 Miles, L.A.; Andronicos, N.M.; Chen, E.I.; Baik, N.; Bai, H.; Parmer, C.M.; Lighvani, S.; Nangia, S.; Kiosses, W.B.; Kamps, M.P.; Yates, J.R., III; Parmer, R.J. Published in under CC BY 3.0 license. Available online: http://dx.doi.org/10.5772/31113 [7].