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. 2021 Feb 8;22(4):1712. doi: 10.3390/ijms22041712

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Enhanced fibrin(ogen) content in Plg-R_KT^−/− wound tissue and effect of fibrinogen heterozygosity on burn wound healing. (A) Immunohistochemical staining for fibrin in the tissue of Plg-R_KT^−/− and Plg-R_KT^+/+ mice collected at different time points after induction of burn wounds (n = 4). Scale bar = 200 µm. (B) Quantification of fibrinogen area in Panel A (%) based on immunostaining using Image J software https://imagej.nih.gov/ij/download.html. (C) Quantification of the remaining wound area at different time points after burn wounding of male Plg-R_KT^−/−/Fgn^+/− (n = 4) mice and Plg-R_KT^+/+/Fgn^+/− mice (n = 5). Post hoc testing was done by Mann–Whitney test. This figure is modified from a figure originally published in [80]. Creative common license available at: http://creativecommons.org/licenses/by/4.0/.