Figure 1.

Multistep molecular pathogenesis of multiple myeloma (MM) Primary and secondary genetic events involved in the MM transformation and progression from the precursor disease entities, such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) to MM, and eventually to extramedullary myeloma/plasma cell leukemia (PCL). Adapted from Chesi M et al. and Manier S et al. [4,5].