Table 2.
Solution/suspension properties of ALZ in PB (pH7) in the presence and absence of polymers.
| Polymers | No Polymer | Eudragit L100 | HPMCAS | PVPVA |
|---|---|---|---|---|
| Solubility, 25 °C (μg/mL) | <0.10 | 0.44 ± 0.02 | 0.47 ± 0.07 | <0.10 |
| Solubility, 37 °C (μg/mL) | <0.10 | 0.32 ± 0.06 | 0.55 ± 0.09 | <0.10 |
| LLPS, 25 °C (μg/mL) | 1.4 | 3.8 | 7.0 | 7.2 |
| Particle size, 25 °C (μm) | >3 | 2.13 ± 0.23 | 0.22 ± 0.02 | 1.12 ± 0.06 |
| Polydispersity Index (PDI) | − | 0.59 ± 0.10 | 0.14 ± 0.02 | 0.21 ± 0.04 |
| Zeta potential, 25 °C (mV) | − | −32.8 ± 1.2 | −12.4 ± 1.1 | −0.2 ± 0.2 |