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PK parameters for oral administration study of ALZ ASDs in rats.
| Formulations | Crystalline ALZ | Eudragit ASD | HPMCAS ASD | PVPVA ASD |
|---|---|---|---|---|
| Cmax (μg/mL) | 2.17 ± 0.54 | 6.30 ± 1.14 | 8.06 ± 0.81 | 8.82 ± 1.44 |
| Tmax (h) | 3.3 ± 1.2 | 4.0 ± 0.0 | 2.0 ± 0.0 | 2.3 ± 1.5 |
| AUC (μg·hr/mL) | 12.7 ± 3.5 | 37.4 ± 4.9 | 48.9 ± 5.4 | 52.4 ± 11.6 |
