Table 4.

PK parameters for oral administration study of ALZ ASDs in beagle dogs.

Formulations	Crystalline ALZ	Eudragit ASD	HPMCAS ASD	HPMCAS ASD Suspension	PVPVA ASD
Cmax (μg/mL)	0.30 ± 0.21	0.44 ± 0.10	0.34 ± 0.09	0.57 ± 0.05	0.20 ± 0.07
Tmax (h)	1.3 ± 0.6	1.7 ± 0.6	2.3 ± 1.5	1.3 ± 0.6	1.3 ± 0.6
AUC (μg·h/mL)	1.93 ± 1.27	2.81 ± 0.47	2.14 ± 0.42	3.04 ± 0.13	1.04 ± 0.41