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. 2021 Feb 7;22(4):1662. doi: 10.3390/ijms22041662

Figure 3.

Figure 3

X-ray structure of paroxetine bind in the binding site of the serotonin transporter (SERT) crystal (a) with the enlarged area showing the structural elements around the ligand-biding site (PDB ID: 5i6x, 3.14 Å) [52]. Residues that form hydrogen bonds (dashed lines) with paroxetine are shown in ball-and-stick representation with the interatomic distances shown in Å. Residues forming Van der Waals interactions with paroxetine are shown as labeled arcs with radial spokes that point toward the ligand atoms (b). Schematic representation of drug interactions in the primary binding pocket of SERT (c) [54].