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. 2021 Feb 9;22(4):1727. doi: 10.3390/ijms22041727

Figure 3.

Figure 3

LCRs in HTT. Fragments of a multiple sequence alignment of HTT orthologs in 10 species. All four polyX detected in HTT are in the fragments shown. The multiple sequence alignment was represented using ClustalX [21]. (A) Human HTT (P42858) positions are 1–95 (not resolved in the 3D structure). (B) Positions 1318–1358, between the cyan and the orange domain (Figure 1 and Figure 2). (C) Positions 2613–2664, within the blue domain. Coordinates shown are from the alignment. No coiled coils (CCs) were detected for HTT orthologs. Sequence identifiers and LCR coordinates and alignments are available as Supplementary Files.