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. 2021 Feb 9;22(4):1727. doi: 10.3390/ijms22041727

Table 3.

LCRs detected in HTT and HAP40. Columns indicate feature type, coordinates in alignment, and conservation in 10 orthologs (as a binary pattern, see Methods for details).

HTT Coordinates Conservation
IDR 1–98 1111100000
polyQ 18–39 1101000000
CBR Q 18–69 1111100000
CBR A 22–83 0000001000
polyP 26–58 1111100000
CBR P 26–90 1111100000
polyP 65–82 1111100000
CBR S 398–705 1111111111
IDR 437–714 1111111111
CBR S 1033–1312 1111100011
IDR 1245–1305 1111111111
CBR P 2171–2193 0000000010
CBR E 2732–2746 1111100100
IDR 2732–2763 1111111100
polyE 2733–2743 1111000000
HAP40 Coordinates Conservation
CBR G 15–88 0000--1000
CBR A 111–347 1111--1000
IDR 285–342 1111--0000
CBR P 291–342 1111--0000
polyP 305–314 1100--0000