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. 2021 Feb 9;22(4):1737. doi: 10.3390/ijms22041737

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Possible treatment strategies for progressive symptoms in patients with severe COVID-19. The incubation period for COVID-19 patients is about 5~6 days (but could be up to 14 days). After the incubation period, patients have common and relatively mild symptoms, including fever and cough. About 80% of COVID-19 patients recover spontaneously, but about 20% develop serious symptoms such as increased inflammation markers and pneumonia. Persistent inflammation and delayed virus removal can cause serious tissue damage to the lungs, kidneys, and heart, which can be fatal. Therefore, immunomodulators should be administered to severely ill patients.