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. 2021 Feb 9;22(4):1726. doi: 10.3390/ijms22041726

Figure 5.

Figure 5

TP53 gene encodes for a protein involved in the control of the cell cycle. When DNA damage occurs, TP53 is able to induce the arrest of the cell cycle, and mutated cells cannot give origin to altered clones. Mutated TP53 loses the ability to stop the growth of mutated cells. Thus, tumoral clones take over.