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. 2021 Feb 7;22(4):1680. doi: 10.3390/ijms22041680

Figure 2.

Figure 2

A simplified view of the relationship between obesity, diabetes and related metabolic disorders and cancer risk (based on [29,30,31,32,33,34,35,36,37,43,44,45,46,47,48,63,64,65,66]). IGFBP—insulin-like growth factor binding protein; SHBG—sex hormone binding globulin; VEGF—vascular endothelial growth factor; PAI-1—plasminogen activator inhibitor-1; TNF-α—tumor necrosis factor-α; MCP-1—Monocyte Chemoattractive Protein-1, CRP—C-reactive protein; IL-6—interleukin-6; IL-1β—interleukin 1β; IL-32—interleukin-32; IR-A—insulin receptor A; ROS—reactive oxygen species; AGE—advanced glycation end-products; RAGE—receptor for AGE; NF-κB—nuclear factor kappa B.